Search Result

Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

cleavable ADC linker

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (2) ADC Linker (647) Drug-Linker Conjugates for ADC (52) Amino Acid Derivatives (1) Antibody-Drug Conjugates (ADCs) (9) Apoptosis (2) Bacterial (4) c-Met/HGFR (1) DNA/RNA Synthesis (1) EGFR (3) Isotope-Labeled Compounds (1) Kinesin (1) Microtubule/Tubulin (9) PROTAC Linkers (201) TAM Receptor (2) Topoisomerase (7)
By Research Areas:	Cancer (703) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (29)
Click Chemistry:	ADC Synthesis (219) TCO (16) DBCO (53) PROTAC Synthesis (57) Azide (66) BCN (21) Tetrazine (30) Alkynes (46)

718

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

226

Click Chemistry

Targets Recommended: ADC Linker Drug-Linker Conjugates for ADC ADC Cytotoxin ADC Antibody Target Protein Ligand-Linker Conjugates PROTAC-Linker Conjugates for PAC E3 Ligase Ligand-Linker Conjugates

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139441

DM21

Drug-Linker Conjugates for ADC Cancer

DM21 is a conjugate of a cleavable ADC agent and a linker (ADC linker) used in the synthesis of antibody-drug conjugates (ADCs) .
HY-114697

DSG Crosslinker

Disuccinimidyl glutarate
ADC Linker Inflammation/Immunology

DSG Crosslinker is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

DM21	Drug-Linker Conjugates for ADC	Cancer
DM21 is a conjugate of a cleavable ADC agent and a linker (ADC linker) used in the synthesis of antibody-drug conjugates (ADCs) .

DSG Crosslinker Disuccinimidyl glutarate	ADC Linker	Inflammation/Immunology
DSG Crosslinker is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) .

HY-118759

DSP Crosslinker 1 Publications Verification	ADC Linker	Inflammation/Immunology
DSP Crosslinker is a cleavable **ADC linker*, used in the synthesis of antibody-drug conjugates (ADCs*) .

HY-135418

Fmoc-Asp-NH2

ADC Linker Cancer

Fmoc-Asp-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-117409

Aminoethyl-SS-ethylalcohol

ADC Linker Cancer

Aminoethyl-SS-ethylalcohol is a glutathione cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
HY-148463

MP-Ala-Ala-PAB

ADC Linker Cancer

MP-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs) .
HY-148461

Mal-VC-PAB-PNP

ADC Linker Cancer

Mal-VC-PAB-PNP is a cleavable ADC linker. Mal-VC-PAB-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .
HY-148462

Fmoc-Ala-Ala-PAB

ADC Linker Cancer

Fmoc-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs) .
HY-148464

MC-Ala-Ala-PAB

ADC Linker Cancer

MC-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs) .
HY-131990

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

ADC Linker Cancer

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

Fmoc-Asp-NH2	ADC Linker	Cancer
Fmoc-Asp-NH2 is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs).

Aminoethyl-SS-ethylalcohol	ADC Linker	Cancer
Aminoethyl-SS-ethylalcohol is a glutathione cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) .

MP-Ala-Ala-PAB	ADC Linker	Cancer
MP-Ala-Ala-PAB is a cleavable **ADC linker*. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs*) .

Mal-VC-PAB-PNP	ADC Linker	Cancer
Mal-VC-PAB-PNP is a cleavable **ADC linker*. Mal-VC-PAB-PNP can be used in the synthesis of antibody-drug conjugates (ADCs*) .

Fmoc-Ala-Ala-PAB	ADC Linker	Cancer
Fmoc-Ala-Ala-PAB is a cleavable **ADC linker*. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs*) .

MC-Ala-Ala-PAB	ADC Linker	Cancer
MC-Ala-Ala-PAB is a cleavable **ADC linker*. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs*) .

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH	ADC Linker	Cancer
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-131990A

MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH	ADC Linker	Cancer
MC-Gly-Gly-{D-Phe}-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-126497

LC-PEG8-SPDP

ADC Linker Cancer

LC-PEG8-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs) .
HY-132261

AcBut

4-(4-Acetyl-phenoxy)-butyric acid
ADC Linker Cancer

AcBut is a cleavable Ozogamicin linker used in the synthesis of Ozogamicin, a agent-linker conjugate for ADC .

LC-PEG8-SPDP	ADC Linker	Cancer
LC-PEG8-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs) .

AcBut 4-(4-Acetyl-phenoxy)-butyric acid	ADC Linker	Cancer
AcBut is a cleavable Ozogamicin linker used in the synthesis of Ozogamicin, a agent-linker conjugate for ADC .

HY-130222

Mal-PEG2-Val-Cit-PAB-OH	ADC Linker PROTAC Linkers	Cancer
Mal-PEG2-Val-Cit-PAB-OH is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-Val-Cit-PAB-OH also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

HY-141597

Acid-C3-SSPy

ADC Linker Cancer

Acid-C3-SSPy is a cleavable DBA-DM4 linker used in the synthesis of DBA-DM4 (HY-128960), a agent-linker conjugate for ADC .

Acid-C3-SSPy	ADC Linker	Cancer
Acid-C3-SSPy is a cleavable DBA-DM4 linker used in the synthesis of DBA-DM4 (HY-128960), a agent-linker conjugate for ADC .

HY-117519

Amino-Tri-(carboxyethoxymethyl)-methane	ADC Linker PROTAC Linkers	Cancer
Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) . Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-117519A

Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride	ADC Linker PROTAC Linkers	Cancer
Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride is a cleavable PEG **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-131955

Fmoc-aminooxy-PEG2-NH2

ADC Linker Cancer

Fmoc-aminooxy-PEG2-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

Fmoc-aminooxy-PEG2-NH2	ADC Linker	Cancer
Fmoc-aminooxy-PEG2-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-141395

m-PEG4-Boc	ADC Linker PROTAC Linkers	Cancer
m-PEG4-Boc is a cleavable 4 unit PEG **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) . m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-132252

Mal-PEG8-Val-Ala-PABC

ADC Linker Cancer

Mal-PEG8-Val-Ala-PABC is a cleavable Tesirine linker used in the synthesis of Tesirine, a agent-linker conjugate for ADC .

Mal-PEG8-Val-Ala-PABC	ADC Linker	Cancer
Mal-PEG8-Val-Ala-PABC is a cleavable Tesirine linker used in the synthesis of Tesirine, a agent-linker conjugate for ADC .

HY-21577

Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine	ADC Linker PROTAC Linkers	Cancer
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-131990G

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH	ADC Linker	Cancer
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-131990). MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-126894

Bis-PEG9-acid	PROTAC Linkers ADC Linker	Cancer
Bis- PEG9- acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis- PEG9- acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

HY-131157

Lys(MMT)-PAB-oxydiacetamide-PEG8-N3	ADC Linker	Cancer
Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a cleavable antibody agent conjugate linker used in the synthesis of antibody-drug conjugates (ADCs) . Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-145951

Amidate-VC-PAB-MMAF	Drug-Linker Conjugates for ADC	Cancer
Amidate-VC-PAB-MMAF consists a cleavable ADC linker (Amidate-VC-PAB) and a potent tubulin polymerization inhibitor (MMAF). Amidate-VC-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs). Amidate-VC-PAB-MMAF reduces off-target cytotoxicity of ADCs .

HY-126893

Bis-PEG8-acid	PROTAC Linkers ADC Linker	Cancer
Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) .

HY-126892

Bis-PEG7-acid	PROTAC Linkers ADC Linker	Cancer
Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) .

HY-140149

Azido-PEG4-Val-Cit-PAB-OH	ADC Linker PROTAC Linkers	Cancer
Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-Val-Cit-PAB-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-140150

Azido-PEG3-Val-Cit-PAB-PNP	ADC Linker PROTAC Linkers	Cancer
Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-130194

Azido-PEG5-CH2CO2H	ADC Linker PROTAC Linkers	Cancer
Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG5-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-130184

Azido-PEG8-NHS ester	ADC Linker PROTAC Linkers	Cancer
Azido-PEG8-NHS ester is a cleavable 8 unit PEG **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG8-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-130474

Azido-PEG6-NHS ester	ADC Linker PROTAC Linkers	Cancer
Azido-PEG6-NHS ester is a cleavable 6 unit PEG **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG6-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-42618

Azido-PEG4-CH2-Boc	ADC Linker PROTAC Linkers	Cancer
Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-118808

Propargyl-PEG2-NHBoc	ADC Linker PROTAC Linkers	Cancer
Propargyl-PEG2-NHBoc is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-130387

Propargyl-PEG4-Tos	PROTAC Linkers ADC Linker	Cancer
Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-42489

N3-PEG3-CH2CH2-Boc	ADC Linker PROTAC Linkers	Cancer
N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) . N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . N3-PEG3-CH2CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-145736A

β-Glucuronide-dPBD-PEG5-NH2 TFA	Drug-Linker Conjugates for ADC Apoptosis	Cancer
β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity .

HY-145736

β-Glucuronide-dPBD-PEG5-NH2	Drug-Linker Conjugates for ADC Apoptosis	Cancer
β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity .

HY-W421970

Tup hydrochloride

ADC Linker Cancer

Tup hydrochloride is a cleavable ADC linker.
HY-44222

MAC glucuronide linker-2

ADC Linker Cancer

MAC glucuronide linker-2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
HY-126670

mDPR(Boc)-Val-Cit-PAB

ADC Linker Cancer

mDPR(Boc)-Val-Cit-PAB is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC) .
HY-12448

SPDB

ADC Linker Cancer

SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) .
HY-126667

SC-Val-Cit-PAB

ADC Linker Cancer

SC-Val-Cit-PAB is a cleavable ADC linker for antibody-drug conjugates (ADCs).
HY-129366

PDB-Pfp

ADC Linker Cancer

PDB-Pfp is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
HY-129368

SPDMV

ADC Linker Cancer

SPDMV is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) .
HY-129369

SPDMB

ADC Linker Cancer

SPDMB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) .
HY-129373

SPDMV-sulfo

ADC Linker Cancer

SPDMV-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
HY-125933

Val-Ala-PAB

ADC Linker Cancer

Val-Ala-PAB is a cleavable ADC linker that can be used for ADCs synthesis .
HY-129370

SPDB-sulfo

ADC Linker Cancer

SPDB-sulfo is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs) .
HY-126531

DMAC-PDB

ADC Linker Cancer

DMAC-PDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

Tup hydrochloride	ADC Linker	Cancer
Tup hydrochloride is a cleavable ADC linker.

MAC glucuronide linker-2	ADC Linker	Cancer
MAC glucuronide linker-2 is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) .

mDPR(Boc)-Val-Cit-PAB	ADC Linker	Cancer
mDPR(Boc)-Val-Cit-PAB is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC) .

SPDB	ADC Linker	Cancer
SPDB is a glutathione cleavable **ADC linker** used for the antibody-drug conjugate (ADCs) .

SC-Val-Cit-PAB	ADC Linker	Cancer
SC-Val-Cit-PAB is a cleavable **ADC linker** for antibody-drug conjugates (ADCs).

PDB-Pfp	ADC Linker	Cancer
PDB-Pfp is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

SPDMV	ADC Linker	Cancer
SPDMV is a glutathione cleavable **ADC linker** used for the antibody-drug conjugate (ADCs) .

SPDMB	ADC Linker	Cancer
SPDMB is a glutathione cleavable **ADC linker** used for the antibody-drug conjugate (ADCs) .

Cat. No.	Product Name	Type

HY-126851

Fluorescein-DBCO	Dyes
Fluorescein-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Fluorescein-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-123687

DBCO-Sulfo-NHS ester sodium	Dyes
DBCO-Sulfo-NHS ester sodium is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-Sulfo-NHS ester (sodium) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-131990G

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)	Fluorescent Dye
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-131990). MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-78921AG

Fmoc-3VVD-OH (GMP)

Fluorescent Dye

Fmoc-3VVD-OH (GMP) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-131833G

Fmoc-Gly-Gly-Phe-OH (GMP)	Fluorescent Dye
Fmoc-Gly-Gly-Phe-OH GMP is a GMP grade Fmoc-Gly-Gly-Phe-OH (HY-131833). Fmoc-Gly-Gly-Phe-OH is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) .

HY-20336G

Mc-Val-Cit-PABC-PNP (GMP)	Fluorescent Dye
Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-19318G

Fmoc-Val-Cit-PAB (GMP)	Fluorescent Dye
Fmoc-Val-Cit-PAB GMP is a GMP grade Fmoc-Val-Cit-PAB (HY-19318). Fmoc-Val-Cit-PAB is a cleavable antibody-conjugated active molecule (ADC) commonly used linker.

HY-42972G

DBCO-acid (GMP)

Fluorescent Dye

DBCO-acid GMP is a GMP grade DBCO-acid (HY-42972). DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690) . DBCO-acid is a click chemistry reagent, itcontains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-W000423G

DBCO-amine (GMP)	Fluorescent Dye
DBCO-amine GMP is a GMP grade DBCO-amine (HY-W000423). DBCO-amine is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-amine is a click chemistry reagent, itcontains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-44980G

Fmoc-Gly-NH-CH2-acetyloxy (GMP)	Fluorescent Dye
Fmoc-Gly-NH-CH2-acetyloxy GMP is a GMP grade Fmoc-Gly-NH-CH2-acetyloxy (HY-44980). Fmoc-Gly-NH-CH2-acetyloxy is a cleavable linker that can be used to synthesize antiboy-drug Conjugates (ADCs).

Cat. No.	Product Name	Type

HY-131990G

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (GMP)	Biochemical Assay Reagents
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-131990). MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-78921AG

Fmoc-3VVD-OH (GMP)

Biochemical Assay Reagents

Fmoc-3VVD-OH (GMP) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-131833G

Fmoc-Gly-Gly-Phe-OH (GMP)	Biochemical Assay Reagents
Fmoc-Gly-Gly-Phe-OH GMP is a GMP grade Fmoc-Gly-Gly-Phe-OH (HY-131833). Fmoc-Gly-Gly-Phe-OH is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) .

HY-20336G

Mc-Val-Cit-PABC-PNP (GMP)	Biochemical Assay Reagents
Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-19318G

Fmoc-Val-Cit-PAB (GMP)	Biochemical Assay Reagents
Fmoc-Val-Cit-PAB GMP is a GMP grade Fmoc-Val-Cit-PAB (HY-19318). Fmoc-Val-Cit-PAB is a cleavable antibody-conjugated active molecule (ADC) commonly used linker.

HY-42972G

DBCO-acid (GMP)

Biochemical Assay Reagents

HY-W000423G

DBCO-amine (GMP)	Biochemical Assay Reagents
DBCO-amine GMP is a GMP grade DBCO-amine (HY-W000423). DBCO-amine is a cleavable **ADC linker** used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-amine is a click chemistry reagent, itcontains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-44980G

Fmoc-Gly-NH-CH2-acetyloxy (GMP)	Biochemical Assay Reagents
Fmoc-Gly-NH-CH2-acetyloxy GMP is a GMP grade Fmoc-Gly-NH-CH2-acetyloxy (HY-44980). Fmoc-Gly-NH-CH2-acetyloxy is a cleavable linker that can be used to synthesize antiboy-drug Conjugates (ADCs).

Cat. No.	Product Name	Target	Research Area

HY-P99593

Sofituzumab vedotin DMUC5754A	Antibody-Drug Conjugates (ADCs)	Cancer
Sofituzumab vedotin (DMUC5754A) is a MMAE-containing anti-MUC16 antibody-drug conjugate (ADC) with a protease-cleavable linker. Sofituzumab vedotin can be used for the research of cancer .

HY-P99101

Vobramitamab AEX-4089	ADC Antibody	Cancer
Vobramitamab is a humanized B7-H3 monoclonal antibody (mAb). Vobramitamab conjugated with prodrug seco-DUBA (HY-132180A) via a cleavable linker, to form antibody-drug conjugate (ADC), the MGC018 .

HY-P99542

Tusamitamab ravtansine SAR-408701; HuMAb2-3-SPDB-DM4	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Tusamitamab ravtansine (SAR-408701) is a targeted *ADC* against tumor cells expressing CEACAM5, composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8 .

HY-P99593A

Sofituzumab vedotin (solution) DMUC5754A (solution)	Antibody-Drug Conjugates (ADCs)	Cancer
Sofituzumab vedotin (DMUC5754A) (solution) is an antibody-drug conjugate (ADC) that contains the humanized IgG1 anti-MUC16 monoclonal antibody and a potent anti-mitotic agent, monomethyl auristatin E (MMAE), linked through a protease-cleavable linker .

HY-P99734

Mipasetamab uzoptirine ADCT-601	TAM Receptor	Cancer
Mipasetamab uzoptirine (ADCT-601) is an AXL-targeted antibody-drug conjugates (ADCs). Mipasetamab uzoptirine consists of a humanized anti-AXL antibody, a cleavable linker and the potent pyrrolobenzodiazepine (PBD) dimer cytotoxin SG3199. Mipasetamab uzoptirine can be used for the research of cancers .

HY-P9988

Mecbotamab BA301	ADC Antibody TAM Receptor	Cancer
Mecbotamab is a humanized IgG1-κ antibody targeting to AXL receptor tyrosine kinase (AXL). Mecbotamab can serves as a conditionally active biologic (CAB), which can be conjugated with MMAE (HY-15162) via a cleavable linker, to form ADC Mecbotamab vedotin (BA3011) .

HY-P99813

Patritumab deruxtecan HER3-DXd	Antibody-Drug Conjugates (ADCs)	Cancer
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity .

HY-P99829

Cofetuzumab pelidotin PF-06647020; ABBV-647; h6M24-vc0101	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting *ADC* comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC₅₀ of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W034918

Docosanedioic acid	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	ADC Linker PROTAC Linkers
Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Cat. No.	Product Name	Chemical Structure

HY-15575S

VcMMAE-d8
VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .

HY-114816S

N-butyryl-L-Homoserine lactone-d5

N-butyryl-L-Homoserine lactone-d₅ is the deuterium labeled N-Butanoyl-L-homoserine lactone. N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1]. N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[2][3].

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cleavable ADC linker

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